Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
You and 9,999 of Your Colleagues
May 04, 2009
The grant-writing frenzy has passed fever pitch and a few numbers are in regarding the Challenge Grants. As of May 1st, Science Insider says that NIH received 10,000 grant applications, though more may come in as some researchers work around problems they had submitting to grants.gov. After crunching some numbers, Science Insider says that if NIH, as it has proposed, funds 200 of the $1 million, two-year grants, the success rate will be 2 percent. Ouch.
what about the recent
what about the recent applications, would this affect them!