This Week in Nature

In Nature this week: 3D organization of human and mouse genomes in both ESCs and differentiated cells, and more.

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The well known saying goes

The well known saying goes like "New things are well forgotten old ones". These topological domains are used to be termed chromatin loops. Interestingly "the insulator binding protein CTCF" was found frequently at the boundaries at the base of these loops. This protein is also found bound to promoters of important genes anchoring them to the base of the loop and protecting from methylation. CTCF inactivating mutations may lead to gene inactivation and remodeling the chromatin.
Michael Lerman, Ph.D., M.D.