Brazilian researchers report in Modern Pathology on their examination of B-cell lymphoma, unclassifiable, a disease that shares characteristics of both diffuse large B-cell lymphoma and classical Hodgkin lymphoma or has features intermediate to those two diseases. The researchers describe the clinicopathological features of 10 cases of B-cell lymphoma, unclassifiable. "Our findings show a male preponderance, median age of 37 years and a mediastinal presentation in 80 percent of cases. All cases expressed at least two markers associated with B-cell lineage and good response to combination chemotherapy currently employed for non-Hodgkin lymphomas," the authors say.
Ohio State University researchers describe their laser capture microdissection-mass spectrometry approach to characterizing glomerular diseases in Modern Pathology. With this approach, the researchers examined the proteomes of glomeruli from normal kidneys as well as samples from patients with diabetic nephropathy, lupus nephritis, and fibronectin glomerulopathy. They report that disease-associated glomeruli had increased levels of complement proteins, though decreased number of proteins associated with podocytes and cellular metabolism. "The most interesting findings from this study are the newly discovered changes in protein expression. This demonstrates that our approach is a robust platform that may inform disease pathogenesis," the Ohio State researchers write.