Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
The Tip of the Legal Iceberg, Folks
Here's a lawsuit raising interesting questions in the field of personal genomics. Kamel at BayBlab talks about the case of a girl born with Fragile X syndrome who "is suing a sperm bank after genetic tests showed the genetic condition was carried on the father's X chromosome," he writes. "In this age of personal genomes and genetic testing, how much responsibility does a sperm bank have to screen for genetic disorders with every available test?" The outcome of the case will likely have direct legal consequences as genetic screening becomes more and more commonplace, he adds.
Ironic...if they would have
Ironic...if they would have screened for fragile X she wouldn't have been born to sue them...