Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Strangely, He Didn't Dwell on Those Dolly Droppings
Martyn Amos blogs about his recent visit to the Wellcome Collection, the Wellcome Trust's museum of genetically interesting bric-a-brac, such as Charles Darwin's walking stick and droppings from Dolly the sheep (seriously). Martyn says the collection's 120-volume printout of the human genome reminded him that "we're rank amateurs compared to nature in the information storage stakes." Still, he notes, "reading and writing data quickly is another matter."