KCTD13 a Driver of Neurodevelopmental Phenotypes Associated with the 16p11.2 CNV
Golzio, Willer et al., Nature
An international team led by investigators at Duke University shows that KCTD13 "is a major driver for the neurodevelopmental phenotypes associated with the 16p11.2 CNV [copy-number variant]," a finding that it says substantiates "the idea that one or a small number of transcripts within a CNV can underpin clinical phenotypes, and offer an efficient route to identifying dosage-sensitive loci."
Renato Dulbecco Dies
February 21, 2012
Renato Dulbecco, the genome sequencing proponent who shared the 1975 Nobel Prize in medicine "for his role in drawing a link between genetic mutations and cancer," has died, reports The New York Times. He was 97. A founding fellow of the Salk Institute for Biological Studies in La Jolla, Calif., Dulbecco's prize-winning work "showed that certain viruses could insert their own genes into infected cells and trigger uncontrolled cell growth, a hallmark of cancer," the Times says, adding that this discovery "provided the first solid evidence that cancer was caused by genetic mutations." In 1986, Dulbecco "proposed cataloging all human genes to gain deeper insights into cancer," the Times reports, thus "providing the intellectual impetus for the Human Genome Project."
Renato Delbecco was a
Renato Delbecco was a legend.I still remember meeting him at a meeting; he came upto me and congratulated me for isolating the first cellular ras oncogene in the form of a rat sarcoma virus.
He did simple experiments to answer big questions. The world needs more of these thinkers and doers.
We will miss him.
Suraiya Rasheed