Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Next Time We Have to Get on an Ark, We'll Really Have to Squeeze In
In yet another year-in-review piece, Wired congratulates genetic engineers by naming "the top 10 organisms that didn't exist on Dec. 31, 2006." Students from the iGEM competition got recognition for creating a strain of E. coli that can produce butanol fuel. GTO was struck by what a good year it was for felines: the Wired list includes glow-in-the-dark cats, hypoallergenic cats, and schizophrenic mice.