Next-gen Challenges

As next-gen sequencing has overcome its early hurdles, newer, higher ones have arisen.

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Good problems to have!

Good problems to have!

It seems that every piece of

It seems that every piece of the puzzle we find and then understand creates a new complete puzzle for us to unravel. Remember the good old "junk" dna days?

Let NGS be a research tool to

Let NGS be a research tool to discover risk markers to be assessed by other methods in the clinic. No point storing raw or uncurated data forever.

De-novo assembly ?

De-novo assembly ?

I agree with you. If you need

I agree with you. If you need to look to a couple of SNP and/or InDel what is the meaning of exploring e Genome/Exome? Even the target sequencing has no sense for daily clinical use.
PS genome price is not only the cost of reagents... and over the cost of the instrument there is time and people needed to analyze it...

I mean, I agree with

I mean, I agree with mkrishnamohan