Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
Minneapolis Lab to Discontinue Thyroid Antibody Testing Tomorrow
Beginning tomorrow, Allina Medical Laboratories will no longer perform its thyroid antibodies test, and will replace it with the thyroid peroxidase antibody assay, the lab said recently.
Allina, which serves Allina Hospitals & Clinics in Minneapolis, said the thyroid peroxidase antibody "is the most sensitive test for detecting autoimmune thyroid disease and has replaced older semiquantitative tests for thyroid antibodies."
TPOAb is "typically the first abnormality to appear in the course of developing hypothyroidism secondary to Hashimotos’ thyroiditis and is found in >95 percent of affected patients."
It is also present in around 85 percent of patients with Graves disease, and is a risk factor for thyroid dysfunction during treatment with interferon alpha, interleukin-2, lithium, and amiodarone.
The antibody is also a risk factor for thyroid dysfunction and post-partum thyroiditis in pregnant women, and "may also be associated" with miscarriage and in vitro fertilization failure.
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