Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
How Do You Plead?
An earthquake hit L'Aquila, a town in the Abruzzo region of Italy, in 2009, and more than 300 people died. Soon thereafter, says Popular Science's Juliet Lapidos, the citizens of L'Aquila requested an investigation into a panel of researchers and civil servants that had previously concluded that a major seismic event was unlikely, despite a series of small tremors that had occurred there. Those researchers are now being charged with manslaughter and could get as much as 15 years in prison. "The L'Aquila judge who determined that the case could go to court said the defendants provided 'imprecise, incomplete and contradictory information' and effectively 'thwarted the activities designed to protect the public,'" Lapidos reports.
Many researchers are saying that holding these seismologists criminally responsible for what happened will have a "chilling effect" on science, Lapidos adds. "If months from now, a court finds the scientists guilty, that would be unfair for them and set a dangerous precedent for panelists on future advisory committees, who might feel reluctant to offer any opinion at all," she says. "The ongoing trial should draw researchers' attention to the benefits of declaiming their own uncertainty, and it should remind the rest of us of the chasm between factual evidence and practical advice."
Predicting the future with
Predicting the future with certainty is as unrealistic an expectation for scientists as for religious fundamentalists. We need to educate the public that scientists can present facts and express opinions about the likelihood of certain future events, but these are statistical probabilities only.