Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
Health Diagnostic Laboratory Now Offering CYP2C19 Testing
June 23, 2010
Health Diagnostic Laboratory has begun offering cytochrome P450 2C19 testing.
Because one of HDL's three specialty areas is cardiac disease, the company singled out the anticoagulant Plavix as the "most notable" drug whose metabolism is influenced by the enzyme.
Echoing the FDA's decision to request a black box warning on the drug's label in March, the Richmond, Va.-based lab said "[c]linicians considering Plavix as a possible preventative therapy for patients should first have their CYP2C19 test results."
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