Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
Harsh Words for HHMI, Max Planck, and Wellcome Trust
Since the Howard Hughes Medical Institute, the Max Plank Society, and the Wellcome Trust announced their launch of a new online-only, open-access genomics journal last month, the move has drawn some criticism. Over at the Great Beyond blog, Nature's Declan Butler — who is a self-proclaimed open-access publishing advocate — questions the groups' rationale for launching such a publication. While he notes that he is not speaking on behalf of his employer, Nature Publishing Group, Butler says that "the three funders' arguments on the need for this new journal seemed to me vague and unconvincing, and poorly thought-out, surprisingly so." He adds that, in his opinion, the groups' "rationale for the new journal, what value it could add, what shortcomings in the existing journal offerings it would address, and how precisely it would achieve this, were similarly disturbingly wooly, and simplistic."
Butler's not the only skeptic. Richard Grant at Confessions of a (Former) Lab Rat, this week also questions how, exactly, the groups plan to launch the proposed journal. According to Grant, the HHMI-Max Planck-Wellcome Trust announcement was more about hype than substance. "Obviously this new Journal with No Name will publish only the best research," he says. "Which means that Wellcome-funded researchers will publish in this journal, and this journal only — obviously, because this is the best journal, and they are the best researchers."
In a guest post at Iddo Friedberg's blog Byte Size Biology, The James Hutton Institute's Leighton Pritchard says that while the new open-access genomics journal is "a great idea," particularly because it has the potential to overcome some of the oft-discussed problems with peer-review, he suggests that it "runs a risk of opening the scientific process to a potentially damaging slander by opponents of science." Pritchard says:
Pritchard goes on to add that, no matter how "ethically clean the journal is," its potential lack of "independence and transparency in the cycle of funding and publication" is threatening. Without independence and transparency, he says, "we risk delivering an opportunity for slander into the hands of those who would undermine science for political goals."
I should also note here, if
I should also note here, if it's not already clear, that in my blog post I was not speaking for my employer, either.
L.
Just to redress the balance a
Just to redress the balance a little, the move has also drawn positive comments. Science magazine had some praise for the idea. Grant Jacobs, at Code for life, says "there is much to like about this initiative". Cameron Neylon on his blog welcomes the new journal.
Right now it seems like
Right now it seems like Drupal is the best blogging platform out there right now. (from what I have read through) Is the fact that what you're working with on your website? clear pores