Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Goings-On in Cancer Genomics
Mass Genomics's Dan Koboldt rounds up a recent cancer genomics meeting in St. Louis, which included talks from Peter Campbell, Richard Gibbs, and Elaine Mardis, among others. Campbell introduced the Wellcome Trust Sanger Institute's first cancer genome; Gibbs spoke about Baylor's multiple-platform approach to whole genome sequencing; and Mardis gave an overview of the strategies being used at Washington University to use next-gen sequencing to study cancer genomes.