Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
Fraud in Primetime
Medical fraud made the primetime news this week as CBS' 60 Minutes had a segment on Anil Potti and his allegedly fraudulent research, which led to his resignation from Duke University. Unfortunately, says Pharmalot's Ed Silverman, it wasn't until it was discovered that Potti had supposedly lied on his résumé about being a Rhodes Scholar that his research was examined in depth by Duke and shown to be problematic.
"It became clear that there was no explanation other than it was a manipulation — a manipulation of the data, a manipulation of somebody's credentials, and a manipulation of a lot of people's trust," says Duke's Joseph Nevins — in whose lab Potti worked — in the 60 Minutes segment. "It simply couldn't be random, it simply couldn't be inadvertent. It had to have been based on a desire to make something work."
In addition, Retraction Watch reports that the Journal of Clinical Oncology has published "mega-corrections" to two more of Potti's studies, each with a dozen or more points of correction. This is in addition to nine Potti studies that have been retracted outright by various journals.