FDA Eyes 'Three-Parent' Babies

FDA looks at human genetic modification for IVF.

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This procedure would not

This procedure would not produce "genetically modified human beings" in the manner that Marcy Danovsky suggests. To declare that mitochondrial DNA is "of the donor" presumes their ownership of that mitochondria. They are merely the carrier of this more functional mitochondria.

Further, the cytoplasmic transfer (which is actually the implanting of the mother's egg cell nucleus into a healthy donor egg cell sans nucleus) is performed to replace the mother's faulty mitochondria with healthy mitochondria which will improve the chances of producing healthier offspring. This mitochondria has its own DNA; the donor's nuclear DNA (which is separate) will not be involved. Succeeding generations will benefit by using the presumably healthier donor mitochondria on through their maternal lineage. (Of course, their ancestry will be confused due to tracing it through assessing mitochondrial mutations--hence the "three-parent" paradox.

Finally, Darnovsky severely understates the prevalence of mitochondrial disorders. Today we know that more diseases are related to respiratory-chain disorders than ever before and that many more of those disorders have been found to be caused by mitochondrial gene defects. These are not rare occurrences.

Please forgive me for not

Please forgive me for not having read the source materials ... is it that the nucleus that is transferred into a healthy donor egg cell sans nucleus must come from the gamete of a female?