Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
A Double-Edged Sword
Over at her blog, Katie PhD says publication requirements for graduate students can be beneficial:
Of course, once they've submitted their work, grad students have little control over the pace of publication. "A prospective PhD student could end up mired in this mess for a really long time through no fault of their own," she says of the peer review process, among other pre-publication procedures. For that and other reasons, Katie PhD says publication requirements can be detrimental: