Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Don't Put This Jelly On Your Sandwich
The Hyphal Tip's Jason Stajich says that the Tremella mesenterica genome is now up at JGI. Tremella mesenterica is a jelly fungus, also called Witch's butter, that Stajich says is interesting to use to study lignin degrading enzymes and wood degradation. Its genome is about 28 megabases with 8,313 predicted genes.