Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
A Conversation with Eric Schadt, Part II
September 22, 2011
Eric Schadt of PacBio and Mount Sinai's Institute for Genomics and Multiscale Biology discusses informatics challenges associated with multiscale biology, cloud computing, and more. (Part I may be found here.)
Produced by Matthew Dublin