Chromosome-Scale Selective Sweeps and Genomic Diversity in C. elegans
Andersen, Gerke et al., Nature Genetics
Researchers at Princeton University and elsewhere discuss the effects of chromosome-scale selective sweeps on genomic diversity in Caenorhabditis elegans. Taking a high-throughput selective sequencing approach on a collection of 200 wild C. elegans strains, the team found that the nematode's "genome variation is dominated by a set of commonly shared haplotypes on four of its six chromosomes, each spanning many megabases." Further, the team reports on its population genetic modeling experiments, which showed that "this pattern was generated by chromosome-scale selective sweeps that have reduced variation worldwide; at least one of these sweeps probably occurred in the last few hundred years," it writes.
Grad School 'Is a Monastic Experience'
September 03, 2010
Continuing with the "what not to do" theme from yesterday, Matthew Might — creator of the "Illustrated Guide to a PhD" — suggests the top 10 reasons grad students don't obtain their PhD at his blog. Might warns PhD candidates against seeking to achieve perfection, aiming too high or too low, procrastinating, trying to "learn too much," and treating grad school like school or work — it's neither, he says — among other things. Grad school, Might says, "is a monastic experience," adding that it "even comes with built-in vows of poverty and obedience. ... The end brings an ecclesiastical robe and a clerical hood."
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