Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
The 'Branching Career Pipeline'
In a paper published online in advance in CBE—Life Sciences Education this week, researchers at the University of California, San Francisco, "advocate for a broader doctoral curriculum that prepares trainees for a wide range of science-related career paths," because, they say, PhD programs of today "continue to prepare students for a traditional academic career path despite the inadequate supply of research-focused faculty positions." To support their stance, the authors report data from survey of UCSF PhD students in the basic biomedical sciences, many of whom "are already considering a broad range of career options" midway through their graduate training. Of the graduate students surveyed, many indicated that their "career path choices [had] shifted during the first three yr [years] of graduate school." The authors add:
To support what the authors call "this branching career pipeline," they suggest that "national standards for training and mentoring include emphasis on career planning and professional skills development to ensure the success of PhD-level scientists as they contribute to a broadly defined global scientific enterprise," UCSF's Office of Career and Professional Development Director Bill Lindstaedt et al. write.