Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
Assistance for Post-Assistant Professors
Science Professor says that while much attention has recently been paid to issues new investigators face, mid-career scientists need mentors and advice as much as their junior colleagues do. She says that deciding "whether and how to pursue tenured positions at other institutions," figuring out "how to use an offer of a job from another institution to negotiate an improvement in our current job," and determining "whether to pursue a part-time or full-time position in administration" are but a few of the mid-career issues scientists can face without much support.
"I do find it's a very tricky topic to approach and the amount of details to give. I applaud your efforts to make sure that mid-career researchers have tools to navigate the (sometimes) tricky waters of work/uni life," blogger 27andaPhD comments. RQ adds: "One of the mid-career issues that I think it under-discussed ... is how to make decisions about the 'rest' of one's career." Planning for the post-assistant and -associate professor stages — asking questions like "is it really a good idea to pursue potentially risky research paths at this juncture?" — is an especially important topic, RQ continues. "I guess this is really all about how to start shifting the intense focus on one's own career that is necessary from graduate school through tenure to a focus that is broader than that without losing the connection to one's specific research interests."
I am now a tenured Associate
I am now a tenured Associate Professor. When I was young, the advice always given was to get everything in writing from the institution making an offer of employment. These days that is very hard to do, more and more things are being promised without specifics, and in the reality such promises can easily be broken or revised with little possibility for rebuttal. Given the surfeit of PhDs looking for academic jobs, there is no question it is a seller's market. Similar issues come up for faculty at more advanced stages of their careers.
I am now a tenured Associate
I am now a tenured Associate Professor. When I was young, the advice always given was to get everything in writing from the institution making an offer of employment. These days that is very hard to do, more and more things are being promised without specifics, and in the reality such promises can easily be broken or revised with little possibility for rebuttal. Given the surfeit of PhDs looking for academic jobs, there is no question it is a seller's market. Similar issues come up for faculty at more advanced stages of their careers.