Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Are You Up With All the Big Papers of the Year?
The Scientist has come up with a list of the top five hottest papers of 2009. Drawing on information from ScienceWatch and ISI, it reports that the top two topics of the year were stem cells and, no surprise to us here, genomics. The second-to-top paper is the Frazer et al Nature paper on the latest HapMap. And coming in first is the Yamanaka group's work on inducing pluripotent stem cells.