Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Ah, Practicality
June 18, 2009
The President's Council on Bioethics was asked to disband last week. The group had been formed by former President Bush in November 2001 and, according to the New York Times, "it was designed by the Bush administration to be 'a philosophically leaning advisory group' that favored discussion over developing a shared consensus," quoting White House press officer Reid Cherlin. President Obama will reconstitute the council with a focus on "practical policy options," Cherlin says. Science Progress adds that "the President is reviewing options for a new council with a revised, policy-focused mandate, but there is currently no public word on a timeframe."