PTB Proteins Induce RNA Looping
Lamichhane, Daubner et al., PNAS
Researchers in the US and Switzerland report that polypyrimidine tract-binding proteins induce RNA looping ― a finding they deduced using FRET, NMR spectroscopy, and in vivo splicing data. They show that two PTB RNA recognition motifs can bind two distant pyrimidine tracts, bringing their 5' and 3' ends in close proximity, thus inducing loop formation.
UPitt Alliance with Clinical Data Could Yield IP Related to PGx Response to mAb Cancer Therapies
The collaboration has the potential to generate new IP surrounding the role FCGR variants play in predicting therapeutic response to IgG1 treatments in a variety of cancers and other diseases – IP in which the University of Pittsburgh would own a stake.
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