Chromosome-Scale Selective Sweeps and Genomic Diversity in C. elegans
Andersen, Gerke et al., Nature Genetics
Researchers at Princeton University and elsewhere discuss the effects of chromosome-scale selective sweeps on genomic diversity in Caenorhabditis elegans. Taking a high-throughput selective sequencing approach on a collection of 200 wild C. elegans strains, the team found that the nematode's "genome variation is dominated by a set of commonly shared haplotypes on four of its six chromosomes, each spanning many megabases." Further, the team reports on its population genetic modeling experiments, which showed that "this pattern was generated by chromosome-scale selective sweeps that have reduced variation worldwide; at least one of these sweeps probably occurred in the last few hundred years," it writes.
Texas A&M System, Xoma to Devise Methods, Build GMP Lab to Make Proteins, Antibodies
The collaboration, which may include the construction of a GMP-rated manufacturing facility at TAMU, could add significant research capabilities and expertise to the school, allow it to score commercial and government biomanufacturing contracts, and bolster translational research, technology commercialization, and biotech-based economic development throughout the state.
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