Startups Amass University IP to Develop Stem Cell ‘Reprogramming’ Tools for Rx Use

December 03, 2007

By Ben Butkus

The two companies, Cascade LifeSciences and Fate Therapeutics, are developing stem cell reprogramming technologies that they believe have greater commercial potential for therapeutic use than recently publicized methods for creating “induced” pluripotent stem cells because they don’t use retroviral vectors or oncogenes.

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In this issue of Biotech Transfer Week

Young Investigator Profile

Sumit Chanda

Associate Professor
Sanford-Burnham Medical Research Institute

Unraveling Complex Host-Pathogen

The Chanda lab is studying cellular proteins required for both influenza A and retrovirus/HIV infection as well as novel molecules that regulate, or respond to, Pattern Recognition Receptor (PRR) signaling. In order to elucidate the repertoire of host proteins required for viral infection, and understand the molecular strategies adapted by these viruses as countermeasures to innate immune response, his lab uses a series of systems-level approaches, including genome-wide RNAi, proteomics and protein-protein interaction (PPI) analysis, and high content imaging. This approach is helping them to build a comprehensive cellular 'roadmap' exploited by these viruses to enable their propagation within a cell.
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A mandatory database would shoulder the fledgling genetic-testing industry — both its private and public sectors — with an unbalanced burden of disclosure.

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Francis Collins on Genetic Tests

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An Honor for Claire Fraser-Liggett

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Papers of Note

Sequencing and Analysis of the Hydra Genome
Chapman, Kirkness et al., Nature
An international research collaboration reports their sequencing and analysis of the Hydra magnipapillata genome, and compare it to the genomes of several other organisms. "The Hydra genome has been shaped by bursts of transposable element expansion, horizontal gene transfer, trans-splicing, and simplification of gene structure and gene content that parallel simplification of the Hydra life cycle," the authors write. They team suggests that comparisons of the Hydra genome to the reported sequences of other animals have helped them to elucidate the evolution of several of the organism's characteristics.

GWAS Identifies Risk Loci for Ulcerative Colitis
Abrecht, Wittig et al., Nature Genetics
Researchers present results from a genome-wide association study which identified risk loci at 7q22 and 22q13 for ulcerative colitis. Their analyses included 1,897,764 SNPs from 1,043 UC cases and 1,703 controls from Germany, and six replication panels from different regions in Europe.
People on the Move

Wellcome Trust Sanger Institute Professor Leena Peltonen-Palotie died this week of cancer at her home in Finland, according to the Sanger Institute. Peltonen-Palotie was head of human genetics at Wellcome Trust, and she held appointments at the Broad Institute at MIT and Harvard and the Institute for Molecular Medicine Finland.

Three leaders from the Human Genome Project — David Botstein, Francis Collins, and Eric Lander — have been named co-winners of the 2010 Albany Medical Center Prize in Medicine and Biomedical Research, which carries with it a purse of $500,000.

Adrian Dillon will resign from his job as executive VP of finance and administration and CFO of Agilent Technologies to become chief financial and administrative officer at Skype. He will be replaced at the beginning of April by Didier Hirsch, who currently is VP of corporate controllership and taxes and who will serve as acting CFO.
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Science
Researchers from the Institute for Systems Biology and elsewhere used Complete Genomics' sequencing service to identify mutations behind a Mendelian condition called Miller syndrome and an inherited lung disorder called ciliary dyskinesia in a family of four.
Business
Bruker will acquire certain mass spectrometry and chromatography product lines from Varian, clearing the way for Agilent to complete its $1.5 billion acquisition of Varian. The divestitures were part of conditions set by EU authorities for approval of the merger.
Funding
HHS expects that in 2010 NIH will spend another roughly $5.2 billion overall in stimulus funds that were left over from ARRA's first year. NIH still has more than $1.6 billion to spend in stimulus funds for lab construction and renovation, buildings and facilities, and shared instruments.
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Startups Amass University IP to Develop Stem Cell ‘Reprogramming’ Tools for Rx Use

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In this issue of Biotech Transfer Week

Young Investigator Profile

Blog

Papers of Note

People on the Move

Upcoming Events

Science

Business

Funding

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