Regulation and Function of miR-218 in Gastric Cancer Metastasis
Tie, Pan et al., PLoS Genetics
Researchers describe a negative feedback system between Robo1, a Slit receptor, and miR-218, wherein “decreased miR-218 levels eliminate Robo1 repression, which activates the Slit-Robo1 pathway through the interaction between Robo1 and Slit2, thus triggering tumor metastasis.” The authors suggest that the restoration of miR-218 supresses Robo1 espression and inhibits tumor cell invasion.
Forma Therapeutics Secures $25M in Private Funds to Buy Discovery Tools
Forma Therapeutics, a drug-discovery company co-founded by scientists from the Broad Institute, has secured an initial $25 million in equity and non-dilutive funding to assemble a drug-discovery toolbox from several academic and corporate entities – although the Broad Institute is not among those potential licensors.
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