Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Proof-of-Concept Center Debuts in Philly to Help Fund Regional Life-Sci Innovators
The multi-institutional Proof of Concept Center will award up to $200,000 over 12 months to fund projects overseen by university tech-transfer offices in the Philadelphia region. Its first RFP will be answered in the summer, officials said.
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