Regulation and Function of miR-218 in Gastric Cancer Metastasis
Tie, Pan et al., PLoS Genetics
Researchers describe a negative feedback system between Robo1, a Slit receptor, and miR-218, wherein “decreased miR-218 levels eliminate Robo1 repression, which activates the Slit-Robo1 pathway through the interaction between Robo1 and Slit2, thus triggering tumor metastasis.” The authors suggest that the restoration of miR-218 supresses Robo1 espression and inhibits tumor cell invasion.
California’s New Life-Science Lobby Alliance Begins Organizing Agenda
The California Life Science Industry Alliance will hold a leadership meeting later this month “where we will be ironing out the details about the action agenda, the structure of the alliance, and future joint activities between the three organizations” — the Southern California Biomedical Council, San Diego-based BIOCOM and BayBio, the life-sci group for the San Francisco Bay Area and northern California.
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