Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
What's the Future of Array-Based GWAS? Sequencing Tech, Study Design, Funding To Impact Growth
Some participants at this year's Human Genome Variation and Complex Genome Analysis meeting believe array-based genome-wide association studies similar to those conducted over the past few years will continue into the future, but several factors will likely affect how the GWAS market develops.
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