Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
UCSF Researchers Win $900K NIH Grant to Create Array-Based Portable Pathogen-Detection System
The team hopes the one-year grant will help it develop a quick, affordable assay that will be deployed in public health laboratories for disease surveillance. The lab is developing the assay to run on a portable instrument from Akonni Biosystems.
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