Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Simulation Study Suggests Rare Variants Could Play Unappreciated Role in GWAS
Duke University researcher David Goldstein and his colleagues suggest that synthetic associations between rare and common variants account for some of the common SNPs identified in genome-wide association studies.
New to GenomeWeb? Register quickly here for free access.