Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
Q&A: U of Liverpool's Andrew Cossins Discusses Using Arrays, RNA-Seq to Study Exotic Species
July 12, 2011
A zoologist by training, Cossins, who runs the university's Institute of Integrative Biology and co-directs its Centre for Genome Research, adopted array technology early to study environmental stress in non-model organisms.
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