Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Progenika Inks Companion-Dx Deal with AMT, Service Pact with ARUP Labs
CEO Antonio Martinez said this week that Progenika plans to engage in more companion diagnostic deals going forward as it develops and commercializes its own tests for familial hypercholesterolemia, drug metabolism, blood group identification, and other applications.
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