Family-Based Whole-Genome Sequencing Reveals Candidates for Mendelian Disease
Roach, Glusman et al., Science
Researchers at the Institute for Systems Biology and Complete Genomics have identified candidate disease-causing genes for Miller syndrome and ciliary dyskinesia, both Mendelian disorders. They sequenced the genomes of a family of four, allowing them to determine recombination sites with precision (at 99.999 percent accuracy) and identify rare single-nucleotide polymorphisms. "Our results demonstrate the unique value of complete genome sequencing in families," the authors write.
New Illumina Suit Alleges Affy's GeneTitan, GeneAtlas, ArrayStation Infringe IP
The suit, the second in six months, alleges that Affy's GeneTitan, GeneAtlas, and ArrayStation instruments infringe US Patent No. 7,612,020, entitled "Composite Arrays Utilizing Microspheres with a Hybridization Chamber."
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