Regulation and Function of miR-218 in Gastric Cancer Metastasis
Tie, Pan et al., PLoS Genetics
Researchers describe a negative feedback system between Robo1, a Slit receptor, and miR-218, wherein “decreased miR-218 levels eliminate Robo1 repression, which activates the Slit-Robo1 pathway through the interaction between Robo1 and Slit2, thus triggering tumor metastasis.” The authors suggest that the restoration of miR-218 supresses Robo1 espression and inhibits tumor cell invasion.
Dutch Researchers Compare Digital Gene Expression Data Across Five Array Platforms
Researchers from Leiden University Medical Center in the Netherlands have found “many advantages of DGE over [traditional] expression microarray technology,” including an “unbiased view” of the transcriptome,” the ability to detect “high levels of differential polyadenylation and antisense transcription,” and high “inter-laboratory comparability of DGE data.” BioArray News spoke with one of the study authors about the research.
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