Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Cost, Data Analysis, and Throughput Keep Array Users from Switching to DGE, Some Say
Though some life sciences tool vendors have pledged that digital gene expression applications performed on their second-generation sequencing platforms will eventually come to dominate the gene-expression market at the expense of arrays, a variety of experts familiar with both technologies say cost, data analysis, and throughput issues are continuing to encourage researchers to choose arrays over DGE.
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