Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Array Companies Upgrade H1N1 Flu Chips Despite Uncertain Market Opportunity
While companies selling array-based tests, including CombiMatrix, Arrayit, and Veredus Labs, are keen to make their platforms available to laboratories for identifying the flu strain, the FDA has only given emergency use authorization for a PCR-based test. Moreover, companies that sell flu chips are unlikely to see their technology adopted unless the current swine flu strain mutates, according to some sources.
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