Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
At AGBT, Pacific Biosciences Unveils Commercial Instrument; Shows 10 kb Read, Variety of Applications
Pacific Biosciences presented its commercial sequencing instrument, the Pacbio RS, publicly for the first time last week, along with a 10-kilobase read generated on the machine and a number of applications, ranging from influenza virus sequencing to structural variation analysis in humans and mutation detection in cancer.
New to GenomeWeb? Register quickly here.